Quinoxaline chemistry. Part 7. 2-[aminobenzoates]- and 2-[aminobenzoylglutamate]-quinoxalines as classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity.
Farmaco
; 52(3): 157-66, 1997 Mar.
Article
in En
| MEDLINE
| ID: mdl-9212450
ABSTRACT
Thirty-three quinoxalines bearing an aminobenzoyl or aminobenzoylglutamate group on position 2 and various substituents on position 3,6,7 of the heterocycle were prepared in order to evaluate in vitro anticancer activity. Preliminary screening performed at NCI showed that most derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10(-5) and 10(-4) Molar concentrations. Interesting selectivities were also recorded between 10(-8) and 10(-6) M. Among the series examined one compound (29) which was the most active also exhibited both in vitro anti-HIV protection and antifungal activity while in other two (31, 37) the antifungal activity was prevailing.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quinoxalines
/
Anti-HIV Agents
/
Folic Acid Antagonists
/
Glutamates
/
Aminobenzoates
/
Antifungal Agents
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Farmaco
Journal subject:
FARMACOLOGIA
/
QUIMICA
Year:
1997
Type:
Article