Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients.

MacFadyen, R J; Barr, C S; Struthers, A D

MacFadyen, R J; Barr, C S; Struthers, A D.

Affiliation

MacFadyen RJ; Department of Clinical Pharmacology, University of Dundee, Ninewells Hospital and Medical School, UK. macfadyen@clinpharm.dundee.ac.uk

Cardiovasc Res ; 35(1): 30-4, 1997 Jul.

Article in En | MEDLINE | ID: mdl-9302344

Subject(s)

Circadian Rhythm; Heart Failure/drug therapy; Heart Rate/drug effects; Mineralocorticoid Receptor Antagonists/therapeutic use; Spironolactone/therapeutic use; Aged; Angiotensin-Converting Enzyme Inhibitors/therapeutic use; Biomarkers/blood; Diuretics/therapeutic use; Double-Blind Method; Drug Therapy, Combination; Electrocardiography, Ambulatory; Female; Fibrosis; Heart Failure/blood; Heart Failure/pathology; Humans; Male; Myocardium/pathology; Peptide Fragments/blood; Procollagen/blood

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Collection: 01-internacional Database: MEDLINE Main subject: Spironolactone / Circadian Rhythm / Mineralocorticoid Receptor Antagonists / Heart Failure / Heart Rate Type of study: Clinical_trials Limits: Aged / Female / Humans / Male Language: En Journal: Cardiovasc Res Year: 1997 Type: Article Affiliation country: United kingdom

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