The effect of kind of carbohydrate in the diet and use of oral contraceptives on metabolism of young women. I. Blood and urinary lactate, uric acid, and phosphorus.

ABSTRACT

Six oral contraceptive (OC) users and six control subjects consumed diets in which 43% of the calories came from either sucrose or starch for 4 weeks in a cross-over design. Kind of carbohydrate in the diet had no effect on blood lactate response to a sucrose load, but lactate response of OC users was greater than that of control subjects. Kind of carbohydrate in the diet did not affect urinary lactate excretion after a sucrose load; however, OC users excreted more lactate than did controls and there was a significant interaction between dietary carbohydrate and OC use. Serum uric acid levels were significantly higher when the sucrose diet was consumed, but levels were not affected by OC use. Serum phosphorus levels were not affected by kind of carbohydrate in the diet but were higher in control subjects than in OC users and there was a significant interaction between diet and OC use. There were no significant differences in urinary uric acid and phosphorus excretions after sucrose loads or in 24-hr urinary excretions of uric acid, phosphorus, or urea due to kind of carbohydrate in the diet or OC use.

ABSTRACT

PIP 6 oral contraceptive (OC) users and 6 control subjects aged 19-25 consumed prepared diets in which 43% of the calories came from either sucrose or starch for 4 weeks in a crossover design. OCs taken were Ovral (1), Ortho-Novum 1/50 (2), Ortho-Novum sequential (1), Oracon sequential (1), and Norlestrin (1). The kind of carbohydrate in the diet had no effect on blood lactate response to a sucrose load, but lactate response of OC users was greater than that of control subjects. Kind of carbohydrate in the diet did not affect urinary lactate excretion after a sucrose load; however, OC users excreted more lactate than did controls and there was a significant interaction between dietary carbohydrate and OC use. Serum uric acid levels were significantly higher when the sucrose diet was consumed, but levels were not affected by OC use. Serum phosphorus levels were not affected by kind of carbohydrate in the diet but were higher in control subjects than in OC users and there was a significant interaction between diet and OC use. There were no significant differences in urinary uric acid and phosphorus excretions after sucrose loads or in 24-hour urinary excretions of uric acid, phosphorus, or urea due to kind of carbohydrate in the diet or OC use.