Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor.

Mantyh, P W; Rogers, S D; Honore, P; Allen, B J; Ghilardi, J R; Li, J; Daughters, R S; Lappi, D A; Wiley, R G; Simone, D A

Mantyh, P W; Rogers, S D; Honore, P; Allen, B J; Ghilardi, J R; Li, J; Daughters, R S; Lappi, D A; Wiley, R G; Simone, D A.

Affiliation

Mantyh PW; Molecular Neurobiology Laboratory (151), Veterans Administration Medical Center, Minneapolis, MN 55417, USA. manty001@maroon.tc.umn.edu

Science ; 278(5336): 275-9, 1997 Oct 10.

Article in En | MEDLINE | ID: mdl-9323204

Subject(s)

Hyperalgesia/therapy; Immunotoxins; N-Glycosyl Hydrolases; Neurons/metabolism; Pain Management; Receptors, Neurokinin-1/metabolism; Spinal Cord/cytology; Substance P/metabolism; Animals; Capsaicin; Cell Membrane/metabolism; Cells, Cultured; Fluorescent Antibody Technique; Hyperalgesia/physiopathology; Injections, Spinal; Neurons/cytology; Pain/physiopathology; Pain Measurement; Plant Proteins/metabolism; Plant Proteins/pharmacology; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1/biosynthesis; Ribosome Inactivating Proteins, Type 1; Saporins; Signal Transduction; Spinal Cord/metabolism; Substance P/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord / Substance P / Immunotoxins / Receptors, Neurokinin-1 / Pain Management / Hyperalgesia / Neurons / N-Glycosyl Hydrolases Limits: Animals Language: En Journal: Science Year: 1997 Type: Article Affiliation country: United States

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