Collagen synthesis by liver stellate cells is released from its normal feedback regulation by acetaldehyde-induced modification of the carboxyl-terminal propeptide of procollagen.

Ma, X; Svegliati-Baroni, G; Poniachik, J; Baraona, E; Lieber, C S

Ma, X; Svegliati-Baroni, G; Poniachik, J; Baraona, E; Lieber, C S.

Affiliation

Ma X; Alcohol Research and Treatment Center, Bronx Veteran Affairs Medical Center, NY 10468, USA.

Alcohol Clin Exp Res ; 21(7): 1204-11, 1997 Oct.

Article in En | MEDLINE | ID: mdl-9347080

Subject(s)

Acetaldehyde/pharmacology; Collagen/biosynthesis; Feedback/drug effects; Liver/cytology; Peptide Fragments/drug effects; Procollagen/drug effects; Animals; Animals, Newborn; Cells, Cultured; Ethanol/pharmacology; Female; Male; Peptide Fragments/physiology; Pregnancy; Procollagen/physiology; Rats; Rats, Sprague-Dawley

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Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Collagen / Procollagen / Feedback / Liver / Acetaldehyde Limits: Animals / Pregnancy Language: En Journal: Alcohol Clin Exp Res Year: 1997 Type: Article Affiliation country: United States

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