Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction.

Perez, G I; Knudson, C M; Leykin, L; Korsmeyer, S J; Tilly, J L

Perez, G I; Knudson, C M; Leykin, L; Korsmeyer, S J; Tilly, J L.

Affiliation

Perez GI; Vincent Center for Reproductive Biology, Massachusetts General Hospital and Department of Obstetrics and Gynecology, Harvard Medical School, Boston 02114, USA.

Nat Med ; 3(11): 1228-32, 1997 Nov.

Article in En | MEDLINE | ID: mdl-9359697

Subject(s)

Antibiotics, Antineoplastic/pharmacology; Apoptosis; Doxorubicin/pharmacology; Lysophospholipids; Oocytes/drug effects; Signal Transduction; Amino Acid Chloromethyl Ketones/pharmacology; Animals; Apoptosis/drug effects; Ceramides/pharmacology; Culture Techniques; Cysteine Proteinase Inhibitors/pharmacology; Female; Leukemia P388/drug therapy; Leukemia P388/pathology; Mice; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; Signal Transduction/drug effects; Sphingosine/analogs & derivatives; Sphingosine/pharmacology; Tumor Cells, Cultured; Tumor Suppressor Protein p53/metabolism; bcl-2-Associated X Protein

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Collection: 01-internacional Database: MEDLINE Main subject: Oocytes / Lysophospholipids / Signal Transduction / Doxorubicin / Apoptosis / Antibiotics, Antineoplastic Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 1997 Type: Article Affiliation country: United States

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