Pyruvate improves deleterious effects of high glucose on activation of pentose phosphate pathway and glutathione redox cycle in endothelial cells.

Kashiwagi, A; Nishio, Y; Asahina, T; Ikebuchi, M; Harada, N; Tanaka, Y; Takahara, N; Taki, H; Obata, T; Hidaka, H; Saeki, Y; Kikkawa, R

Kashiwagi, A; Nishio, Y; Asahina, T; Ikebuchi, M; Harada, N; Tanaka, Y; Takahara, N; Taki, H; Obata, T; Hidaka, H; Saeki, Y; Kikkawa, R.

Affiliation

Kashiwagi A; Third Department of Medicine, Shiga University of Medical Science, Japan.

Diabetes ; 46(12): 2088-95, 1997 Dec.

Article in En | MEDLINE | ID: mdl-9392501

Subject(s)

Endothelium, Vascular/drug effects; Endothelium, Vascular/metabolism; Glucose/pharmacology; Glutathione/metabolism; Pentose Phosphate Pathway/drug effects; Pyruvic Acid/pharmacology; Adenosine Triphosphate/metabolism; Cells, Cultured; Fructosediphosphates/metabolism; Glucose/administration & dosage; Humans; Hydrogen Peroxide/metabolism; Hydrogen Peroxide/pharmacology; Lactic Acid/metabolism; NAD/metabolism; NADP/metabolism; Oxidation-Reduction; Pyruvic Acid/metabolism; Umbilical Veins

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Collection: 01-internacional Database: MEDLINE Main subject: Pentose Phosphate Pathway / Endothelium, Vascular / Pyruvic Acid / Glucose / Glutathione Limits: Humans Language: En Journal: Diabetes Year: 1997 Type: Article Affiliation country: Japan

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