Inactivation of p53 in normal human cells increases G2/M arrest and sensitivity to DNA-damaging agents.

Céraline, J; Deplanque, G; Duclos, B; Limacher, J M; Hajri, A; Noel, F; Orvain, C; Frébourg, T; Klein-Soyer, C; Bergerat, J P

Céraline, J; Deplanque, G; Duclos, B; Limacher, J M; Hajri, A; Noel, F; Orvain, C; Frébourg, T; Klein-Soyer, C; Bergerat, J P.

Affiliation

Céraline J; Laboratoire d'Oncologie Moléculaire, Institut de Recherche contre les Cancers de l'Appareil Digestif, Hôpitaux Universitaires de Strasbourg, France.

Int J Cancer ; 75(3): 432-8, 1998 Jan 30.

Article in En | MEDLINE | ID: mdl-9455805

Subject(s)

Antineoplastic Agents/pharmacology; Cisplatin/pharmacology; DNA Damage; G2 Phase/physiology; Gene Expression Regulation/physiology; Genes, p53; Mitosis/physiology; Oligonucleotides, Antisense/pharmacology; Radiation Tolerance/physiology; Base Sequence; Cells, Cultured; DNA/drug effects; DNA/metabolism; DNA/radiation effects; Drug Screening Assays, Antitumor; Fibroblasts/drug effects; Fibroblasts/metabolism; Fibroblasts/radiation effects; G2 Phase/drug effects; G2 Phase/radiation effects; Humans; Mitosis/drug effects; Mitosis/radiation effects; Molecular Sequence Data; Mutation; Tumor Suppressor Protein p53/biosynthesis; Ultraviolet Rays/adverse effects

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Collection: 01-internacional Database: MEDLINE Main subject: Radiation Tolerance / DNA Damage / Gene Expression Regulation / G2 Phase / Genes, p53 / Oligonucleotides, Antisense / Cisplatin / Mitosis / Antineoplastic Agents Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Int J Cancer Year: 1998 Type: Article Affiliation country: France

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