Phenytoin alters the disposition of topotecan and N-desmethyl topotecan in a patient with medulloblastoma.

Zamboni, W C; Gajjar, A J; Heideman, R L; Beijnen, J H; Rosing, H; Houghton, P J; Stewart, C F

Zamboni, W C; Gajjar, A J; Heideman, R L; Beijnen, J H; Rosing, H; Houghton, P J; Stewart, C F.

Affiliation

Zamboni WC; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Clin Cancer Res ; 4(3): 783-9, 1998 Mar.

Article in En | MEDLINE | ID: mdl-9533548

Subject(s)

Antineoplastic Agents/pharmacokinetics; Antineoplastic Agents/therapeutic use; Cerebellar Neoplasms/drug therapy; Medulloblastoma/drug therapy; Phenytoin/therapeutic use; Topotecan/analogs & derivatives; Topotecan/pharmacokinetics; Topotecan/therapeutic use; Anticonvulsants/therapeutic use; Antineoplastic Agents/blood; Cerebellar Neoplasms/blood; Cerebellar Neoplasms/surgery; Child, Preschool; Drug Interactions; Humans; Lactones; Male; Medulloblastoma/blood; Medulloblastoma/surgery; Metabolic Clearance Rate; Models, Biological; Topotecan/blood; Topotecan/cerebrospinal fluid

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Collection: 01-internacional Database: MEDLINE Main subject: Phenytoin / Cerebellar Neoplasms / Topotecan / Medulloblastoma / Antineoplastic Agents Type of study: Prognostic_studies Limits: Child, preschool / Humans / Male Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 1998 Type: Article Affiliation country: United States

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