Possible mechanism of the negative inotropic effect of alpha1-adrenoceptor agonists in rat isolated left atria after exposure to free radicals.

Peters, S L; Batink, H D; Michel, M C; Pfaffendorf, M; van Zwieten, P A

Peters, S L; Batink, H D; Michel, M C; Pfaffendorf, M; van Zwieten, P A.

Affiliation

Peters SL; Department of Pharmacotherapy, Academic Medical Centre, University of Amsterdam, The Netherlands.

Br J Pharmacol ; 123(5): 952-8, 1998 Mar.

Article in En | MEDLINE | ID: mdl-9535025

Subject(s)

Adrenergic alpha-1 Receptor Agonists; Heart Atria/drug effects; Methoxamine/pharmacology; Myocardial Contraction/drug effects; Adrenergic alpha-Agonists/pharmacology; Animals; Atrial Function; Enzyme Inhibitors/pharmacology; Free Radicals; Heart Atria/metabolism; In Vitro Techniques; Inositol Phosphates/metabolism; Male; Naphthalenes/pharmacology; Ouabain/pharmacology; Oxidative Stress; Protein Kinase C/antagonists & inhibitors; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1/metabolism; Signal Transduction; Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors; Sodium-Potassium-Exchanging ATPase/biosynthesis; Sodium-Potassium-Exchanging ATPase/metabolism; Type C Phospholipases/biosynthesis; Type C Phospholipases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adrenergic alpha-1 Receptor Agonists / Heart Atria / Methoxamine / Myocardial Contraction Limits: Animals Language: En Journal: Br J Pharmacol Year: 1998 Type: Article Affiliation country: Netherlands

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