Presenilin 1 is actively degraded by the 26S proteasome.
Neurobiol Aging
; 19(1 Suppl): S19-21, 1998.
Article
in En
| MEDLINE
| ID: mdl-9562462
ABSTRACT
The metabolic pathways governing the turnover of presenilin 1 (PS1) have been incompletely worked out. The PS1 holoprotein has low abundance in many cells and appears to undergo endoproteolytic cleavage near residue 298. We provide evidence that one mechanism by which the PS1 holoprotein is degraded is through the action of the 26S proteasome. We also show that the proteasome does not participate in the endoproteolytic cleavage.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptide Hydrolases
/
Proteasome Endopeptidase Complex
/
Alzheimer Disease
/
Membrane Proteins
Limits:
Animals
/
Humans
Language:
En
Journal:
Neurobiol Aging
Year:
1998
Type:
Article
Affiliation country:
Canada