Effect of heparin on hemagglutination by equine arteritis virus.
J Vet Med Sci
; 60(4): 447-50, 1998 Apr.
Article
in En
| MEDLINE
| ID: mdl-9592716
ABSTRACT
Heparin inhibited hemagglutination (HA) by equine arteritis virus (EAV) as well as did HA by Aujeszky's disease virus (ADV), but failed to inhibit HA by parainfluenza virus type 3 (PIV-3). The minimal concentration of heparin required to inhibit 8 HA U of EAV was 0.1 U/ml. In addition, most EAV hemagglutinin was retained by heparin acrylic beads, as was ADV hemagglutinin, but was not PIV-3 hemagglutinin. Mouse erythrocytes failed to combine with the HA inhibitory factor of heparin. However, mouse erythrocytes treated with heparinase had greatly reduced agglutinability by EAV. All these findings suggest that a heparin-like molecule on the surface of mouse erythrocytes serves as the virus-cell receptor.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Heparin
/
Equartevirus
/
Hemagglutination
Limits:
Animals
Language:
En
Journal:
J Vet Med Sci
Journal subject:
MEDICINA VETERINARIA
Year:
1998
Type:
Article
Affiliation country:
Japan