The PML/RARalpha fusion protein inhibits tumor necrosis factor-alpha-induced apoptosis in U937 cells and acute promyelocytic leukemia blasts.

Testa, U; Grignani, F; Samoggia, P; Zanetti, C; Riccioni, R; Lo Coco, F; Diverio, D; Felli, N; Passerini, C G; Grell, M; Pelicci, P G; Peschle, C

Testa, U; Grignani, F; Samoggia, P; Zanetti, C; Riccioni, R; Lo Coco, F; Diverio, D; Felli, N; Passerini, C G; Grell, M; Pelicci, P G; Peschle, C.

Affiliation

Testa U; Department of Hematology-Oncology, Istituto Superiore di Sanità, 00161 Rome, Italy.

J Clin Invest ; 101(10): 2278-89, 1998 May 15.

Article in En | MEDLINE | ID: mdl-9593784

Subject(s)

Apoptosis/physiology; Leukemia, Promyelocytic, Acute/metabolism; Neoplasm Proteins/genetics; Nuclear Proteins; Receptors, Retinoic Acid/genetics; Recombinant Fusion Proteins/physiology; Transcription Factors/genetics; Tumor Necrosis Factor-alpha/toxicity; Antigens, CD/analysis; Antigens, CD/immunology; Cell Division/drug effects; Cell Division/genetics; Cell Survival/drug effects; Cell Survival/genetics; Gene Expression Regulation, Neoplastic/genetics; Humans; Promyelocytic Leukemia Protein; Protein Binding/drug effects; RNA, Messenger/analysis; Receptors, Tumor Necrosis Factor/agonists; Receptors, Tumor Necrosis Factor/immunology; Retinoic Acid Receptor alpha; Transfection; Tumor Cells, Cultured; Tumor Suppressor Proteins; fas Receptor/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Recombinant Fusion Proteins / Nuclear Proteins / Leukemia, Promyelocytic, Acute / Tumor Necrosis Factor-alpha / Apoptosis / Receptors, Retinoic Acid / Neoplasm Proteins Limits: Humans Language: En Journal: J Clin Invest Year: 1998 Type: Article Affiliation country: Italy

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