Idiotypic immunization induces immunity to mutated p53 and tumor rejection.
Nat Med
; 4(6): 710-2, 1998 Jun.
Article
in En
| MEDLINE
| ID: mdl-9623981
ABSTRACT
The p53 molecule might serve as a common tumor-associated antigen, as the tumor suppressor gene p53 is mutated and the p53 protein is often over-expressed in tumor cells. We report that effective immunity to p53 can be induced through an idiotypic network by immunization of mice with a monoclonal antibody (PAb-240) specific for mutated p53, or with a peptide derived from the complementarity determining region (CDR) 3 of the variable domain of the light chain (VL) of this antibody. The immunized mice produced IgG antibodies to p53 and mounted a cytotoxic reaction to a tumor line bearing mutated p53. The idiotypically immunized mice were resistant to challenge with the tumor cells. Thus antibodies to p53 might serve as immunogens for activating resistance to some tumors. At the basic level, these findings indicate that a network of p53 immunity may be organized naturally within the immune system.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antibodies, Anti-Idiotypic
/
Tumor Suppressor Protein p53
/
Antibodies, Monoclonal
/
Neoplasms, Experimental
Limits:
Animals
Language:
En
Journal:
Nat Med
Journal subject:
BIOLOGIA MOLECULAR
/
MEDICINA
Year:
1998
Type:
Article
Affiliation country:
United States