Sotalol associated polymorphic ventricular tachycardia and coronary spasm.
Heart
; 79(5): 518-20, 1998 May.
Article
in En
| MEDLINE
| ID: mdl-9659206
ABSTRACT
Sotalol may induce torsade de pointes through cardiac action potential prolongation, but a proarrhythmic effect secondary to its beta blocking action has not been reported. A 54 year old man presented with symptoms of angina and presyncope, subsequently demonstrated to be associated with coronary spasm. Treatment with sotalol exacerbated his symptoms and resulted in recurrent polymorphic ventricular tachycardia with a pattern indistinguishable from that caused by a class III action. Following sotalol with-drawal polymorphic ventricular tachycardia resolved completely. Polymorphic ventricular tachycardia in patients treated with sotalol may therefore not always be the result of delayed repolarisation, but may be caused by beta adrenoceptor blockade.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sotalol
/
Tachycardia, Ventricular
/
Adrenergic beta-Antagonists
Type of study:
Diagnostic_studies
/
Risk_factors_studies
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Heart
Journal subject:
CARDIOLOGIA
Year:
1998
Type:
Article
Affiliation country:
United kingdom