Antinuclear antibody seropositivity in patients with cutaneous T-cell lymphoma.
J Am Acad Dermatol
; 39(3): 434-8, 1998 Sep.
Article
in En
| MEDLINE
| ID: mdl-9738778
ABSTRACT
BACKGROUND:
We attempted to determine the frequency and clinical relevance of antinuclear antibody (ANA) testing and positive ANA test results in patients with cutaneous T-cell lymphoma (CTCL).METHODS:
A retrospective chart and computer record review was conducted to determine the frequency of ANA testing in CTCL patients and the rate of seropositivity. Patients with a positive ANA were further examined to define possible explanations of the positive test.RESULTS:
Of 381 patients with CTCL, 66 (17%) had ANA tests; 8 of these (12.1%) were found to have an ANA titer greater than or equal to 140. Of patients with a positive ANA test, one was found to have chronic cutaneous lupus erythematosus histologically and clinically mimicking CTCL. Others were found to have a comorbid connective tissue disorder, some had apparent drug-induced antinuclear antibodies, and some had no identifiable reason for a positive ANA test.CONCLUSION:
ANA seropositivity does not appear to be increased in CTCL patients, and the ANA test remains a useful screening tool for differentiating between CTCL and connective tissue disorders.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Neoplasms
/
Antibodies, Antinuclear
/
Lymphoma, T-Cell, Cutaneous
/
Mycosis Fungoides
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Am Acad Dermatol
Year:
1998
Type:
Article
Affiliation country:
United States