Different effects of newly isolated saponins on the mutagenicity and cytotoxicity of the anticancer drugs mitomycin C and bleomycin in human lymphocytes.

Scarpato, R; Bertoli, A; Naccarati, A; Migliore, L; Cocchi, L; Barale, R; Pistelli, L

Scarpato, R; Bertoli, A; Naccarati, A; Migliore, L; Cocchi, L; Barale, R; Pistelli, L.

Affiliation

Scarpato R; Dipartimento di Scienze dell'Uomo e dell'Ambiente, Università di Pisa, Via San Giuseppe 22, 56100, Pisa, Italy.

Mutat Res ; 420(1-3): 49-54, 1998 Dec 03.

Article in En | MEDLINE | ID: mdl-9838039

ABSTRACT

ABSTRACT

Aim of the present paper was to assess by using the in vitro micronucleus (MN) test in human lymphocytes the effect of two plant extracts isolated from Blupeurum fruticosum (saponins) on the clastogenicity and cytotoxicity of the anticancer drugs mitomycin C (MMC) and bleomycin (BLM). One saponin showed a dose-dependent MMC-induced mutagenesis inhibition together with co-genotoxic effect on BLM-treated cultures. The remaining saponin did not significantly alter MN induction of both chemotherapeutic agents whereas it enhanced BLM cytotoxicity.

Subject(s)

Antimetabolites, Antineoplastic/toxicity; Bleomycin/toxicity; Mitomycin/toxicity; Nucleic Acid Synthesis Inhibitors/toxicity; Saponins/pharmacology; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Lymphocytes/chemistry; Lymphocytes/drug effects; Male; Micronucleus Tests; Mutagens/pharmacology; Plants/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Saponins / Bleomycin / Mitomycin / Nucleic Acid Synthesis Inhibitors / Antimetabolites, Antineoplastic Limits: Humans / Male Language: En Journal: Mutat Res Year: 1998 Type: Article Affiliation country: Italy

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