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Correlation of activated monocytes or B cells with T lymphocyte subsets in patients with Graves' disease.
González, A; Calleja, A; Santiago, E; De Miguel, C; López-Zabalza, M J; López-Moratalla, N.
Affiliation
  • González A; Department of Biochemistry, University of Navarra, Pamplona, Spain.
Int J Mol Med ; 1(1): 95-103, 1998 Jan.
Article in En | MEDLINE | ID: mdl-9852205
ABSTRACT
We analyzed the phenotypic characteristics of PBMC from 34 patients with Graves' disease (GD) at different stages of the disease to explore the sequence of immunological events associated with it. In all cases their monocytes were in a state of activation and differentiation more advanced than those of a group of 23 healthy individuals. Strikingly, some patients had CD14++DR- immature monocytes, which were absent in healthy individuals. CD14+CD16+DRhigh monocytes were more abundant in patients. We found a positive correlation between the CD14++DR- monocyte and CD4+CD45RA- helper cells and a negative correlation between the same monocyte subset and CD4+CD45RA+ naive cells. CD14+/++DRlow monocytes directly correlated with this latter T4 subset and CD14+ CD16+DRhigh with CD4+CD45RO+ memory lymphocytes. There was also a positive correlation between memory T4 cells and the subset of activated B lymphocytes (CD19+CD5+) and suppressor T8 cells (CD8+CD11b+). T8 cytotoxic cells (CD8+CD11b-) positively correlated with T4 naive cells. The circulating levels of T3 and TSI (thyroid-stimulating immunoglobulin) directly correlated with a decrease in naive cells and an increase in T8 suppressors. The results suggest that the imbalance suppression/cytotoxicity in GD may be due to a reiterated presentation of autoantigens, or mimetic antigens, to T helpers by mature monocytes and activated B cells.
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: Leukocytes, Mononuclear / B-Lymphocytes / Lymphocyte Activation / Graves Disease / T-Lymphocyte Subsets Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: Int J Mol Med Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 1998 Type: Article Affiliation country: Spain
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Collection: 01-internacional Database: MEDLINE Main subject: Leukocytes, Mononuclear / B-Lymphocytes / Lymphocyte Activation / Graves Disease / T-Lymphocyte Subsets Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: Int J Mol Med Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 1998 Type: Article Affiliation country: Spain