Intrinsic defects in macrophage IL-12 production associated with immune dysfunction in the MRL/++ and New Zealand Black/White F1 lupus-prone mice and the Leishmania major-susceptible BALB/c strain.

Alleva, D G; Kaser, S B; Beller, D I

Alleva, D G; Kaser, S B; Beller, D I.

Affiliation

Alleva DG; Evans Memorial Department of Clinical Research, Boston University Medical Center, MA 02118-2393, USA.

J Immunol ; 161(12): 6878-84, 1998 Dec 15.

Article in En | MEDLINE | ID: mdl-9862720

Subject(s)

Autoimmune Diseases/immunology; Interleukin-12/deficiency; Leishmania major; Leishmaniasis, Cutaneous/immunology; Lupus Erythematosus, Systemic/immunology; Macrophages, Peritoneal/metabolism; Mice, Inbred Strains/immunology; Animals; Autoimmune Diseases/metabolism; Autoimmune Diseases/pathology; Autoimmunity; Cells, Cultured; Crosses, Genetic; Culture Media, Conditioned/chemistry; Gene Expression Regulation; Genetic Predisposition to Disease; Interferon-gamma/pharmacology; Interleukin-1/biosynthesis; Interleukin-1/deficiency; Interleukin-1/genetics; Interleukin-10/biosynthesis; Interleukin-10/genetics; Interleukin-12/biosynthesis; Interleukin-12/genetics; Interleukin-6/biosynthesis; Interleukin-6/deficiency; Interleukin-6/genetics; Leishmaniasis, Cutaneous/metabolism; Leishmaniasis, Cutaneous/pathology; Lupus Erythematosus, Systemic/metabolism; Lupus Erythematosus, Systemic/pathology; Macrophages, Peritoneal/pathology; Male; Mice; Mice, Inbred BALB C; Mice, Inbred NZB; Mice, Inbred Strains/genetics; Recombinant Proteins/pharmacology; Species Specificity; Th1 Cells/immunology; Th1 Cells/pathology; Tumor Necrosis Factor-alpha/biosynthesis; Tumor Necrosis Factor-alpha/deficiency; Tumor Necrosis Factor-alpha/genetics

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Leishmaniasis, Cutaneous / Macrophages, Peritoneal / Leishmania major / Interleukin-12 / Lupus Erythematosus, Systemic / Mice, Inbred Strains Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: J Immunol Year: 1998 Type: Article Affiliation country: United States

Search on Google

XML

PubMed Links