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Cytogenetic changes in two cases of subependymal giant-cell astrocytoma.
Debiec-Rychter, M; Jesionek-Kupnicka, D; Zakrzewski, K; Liberski, P P.
Affiliation
  • Debiec-Rychter M; Laboratory of Tumor Biology, Medical School of Lodz, Poland.
Cancer Genet Cytogenet ; 109(1): 29-33, 1999 Feb.
Article in En | MEDLINE | ID: mdl-9973956
ABSTRACT
Cytogenetic analysis of subependymal giant-cell astrocytomas (SEGAs) from two patients presenting the clinical symptoms of tuberous sclerosis complex (TSC) revealed clonal chromosomal changes, resulting in the partial loss of chromosome 22q in both tumors. Immunohistochemically, tumors exhibited features of glial differentiation, while ultrastructural studies identified the characteristic paracrystalline inclusions within the tumor cells. To our knowledge, it is the first cytogenetic description of SEGAs associated with TSC.
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Collection: 01-internacional Database: MEDLINE Main subject: Chromosomes, Human, Pair 22 / Brain Neoplasms / Chromosome Deletion / Glioma Type of study: Diagnostic_studies / Prognostic_studies Limits: Child / Humans / Male Language: En Journal: Cancer Genet Cytogenet Year: 1999 Type: Article Affiliation country: Poland
Search on Google
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Chromosomes, Human, Pair 22 / Brain Neoplasms / Chromosome Deletion / Glioma Type of study: Diagnostic_studies / Prognostic_studies Limits: Child / Humans / Male Language: En Journal: Cancer Genet Cytogenet Year: 1999 Type: Article Affiliation country: Poland