Ontogeny of ATP and ADP hydrolysis by cerebral cortex synaptosomes from rats
Braz. j. med. biol. res
; 23(10): 935-9, 1990. tab
Article
en En
| LILACS
| ID: lil-91629
Biblioteca responsable:
BR26.1
RESUMO
In the present study, we examined the ontogeny of ATP and ADP hydrolysis by cerebral cortex symptosomes from rats of various ages (0-, 7-, 14-, 21- and 60 to 90-day-old rats) in order to learn whether hydrolytic activity increases during the period of intense brain grwth, as has been reported for other enzymes involved in neurotransmitter metabolism. the results demonstrate that ATP and ADP hydrolyzing activities increase in parallel from birth until the second postnatal week (about 4-fold), followed by a slight and statistically insignificant increase until the animal reaches adulthood. The maximum increase in nucleotide hidrolysis coincided with mximum brain growth, which may indicate a role for the enzyme in neurotransmission. Furthermore, the parallel development of both activities (ATPase and ADPase) strongly suggest that a single enzyme, an ATP diphosphohydrolase, is involved in ATP and ADP hydrolisis by the synaptosomal fraction
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Colección:
01-internacional
Banco de datos:
LILACS
Asunto principal:
Sinaptosomas
/
Adenosina Difosfato
/
Corteza Cerebral
/
Adenosina Trifosfato
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Crecimiento
Límite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1990
Tipo del documento:
Article
/
Congress and conference