Localization of Sonic hedgehog secreting and receiving cells in the developing and adult rat adrenal cortex.
Mol Cell Endocrinol
; 336(1-2): 117-22, 2011 Apr 10.
Article
en En
| MEDLINE
| ID: mdl-21094676
ABSTRACT
Sonic hedgehog signaling was recently demonstrated to play an important role in murine adrenal cortex development. The organization of the rat adrenal differs from that of the mouse, with the zona glomerulosa and zona fasciculata separated by an undifferentiated zone in the rat, but not in the mouse. In the present study we aimed to determine the mRNA expression patterns of Sonic hedgehog and the hedgehog signaling pathway components Patched-1 and Gli1 in the developing and adult rat adrenal. Sonic hedgehog expression was detected at the periphery of the cortex in cells lacking CYP11B1 and CYP11B2 expression, while signal-receiving cells were localized in the overlying capsule mesenchyme. Using combined in situ hybridization and immunohistochemistry we found that the cells expressing Sonic hedgehog lie between the CYP11B2 and CYP11B1 layers, and thus Sonic hedgehog expression defines one cell population of the undifferentiated zone.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Corteza Suprarrenal
/
Proteínas Hedgehog
Límite:
Animals
Idioma:
En
Revista:
Mol Cell Endocrinol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido