NudC is required for interkinetic nuclear migration and neuronal migration during neocortical development.
Dev Biol
; 357(2): 326-35, 2011 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-21771589
ABSTRACT
NudC is a highly conserved protein necessary for cytoplasmic dynein-mediated nuclear migration in Aspergillus nidulans. NudC interacts genetically with Aspergillus NudF and physically with its mammalian orthologue Lis1, which is crucial for nuclear and neuronal migration during brain development. To test for related roles for NudC, we performed in utero electroporation into embryonic rat brain of cDNAs encoding shRNAs as well as wild-type and mutant forms of NudC. We show here that NudC, like Lis1, is required for neuronal migration during neocorticogenesis and we identify a specific role in apical nuclear migration in radial glial progenitor cells. These results identify a novel neuronal migration gene with a specific role in interkinetic nuclear migration, consistent with cytoplasmic dynein regulation.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Nucleares
/
Movimiento Celular
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Núcleo Celular
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Neocórtex
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Dev Biol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos