Evaluation of acute infection-induced endothelial dysfunction and its potential mediators.
Acta Cardiol
; 66(5): 581-7, 2011 Oct.
Article
en En
| MEDLINE
| ID: mdl-22032051
ABSTRACT
OBJECTIVES:
Inflammation plays an important role in the pathophysiology of atherosclerosis. Some studies suggest a link between chronic infections, an inflammatory state, and endothelial dysfunction. However, data related to acute infections are scant. We have investigated (i) the effect of acute infection on endothelial function; (ii) the role of potential mediators of endothelial dysfunction.METHODS:
Forty patients 40 years old with acute infection (mean age 53.9 +/- 8.8 years), without coronary artery disease or its equivalents were enrolled. Endothelial function and blood levels of high sensitive C-reactive protein, interleukin-6, tumour necrosis factor-a, high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), apolipoprotein-A1 (Apo-A1) and apolipoprotein-B100 (Apo-B100) were assessed in the acute infection phase and 1 month after recovery. Endothelial function was evaluated by brachial artery flow-mediated vasodilation (FMD).RESULTS:
The intraclass correlation coefficients for intra- and interobserver agreement for FMD measurements were 0.98 (95% CI 0.95-0.99) and 0.93 (95% CI 0.83-0.97), respectively. FMD improved significantly 1 month after recovery (P < 0.001). Compared to the levels at 1 month, inflammatory markers, LDL cholesterol, LDL/HDL ratio, Apo-B100 and Apo-B100/Apo-A1 ratio were significantly higher. However, HDL and apo-A1 were significantly lower in the phase of acute infection. Change in FMD from baseline to 1 month after recovery correlated significantly only with the change in Apo-A1 (r = 0.35, P = 0.027).CONCLUSIONS:
Acute infection causes transient endothelial dysfunction. It increases inflammatory markers and generates an atherogenic lipid profile. Among the parameters evaluated, only the change in Apo-A1 level was associated with acute infection-induced endothelial dysfunction.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Infecciones del Sistema Respiratorio
/
Enfermedad de la Arteria Coronaria
/
Arteria Braquial
/
Endotelio Vascular
/
Inflamación
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Acta Cardiol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Turquía