Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.

Kool, Marcel; Jones, David T W; Jäger, Natalie; Northcott, Paul A; Pugh, Trevor J; Hovestadt, Volker; Piro, Rosario M; Esparza, L Adriana; Markant, Shirley L; Remke, Marc; Milde, Till; Bourdeaut, Franck; Ryzhova, Marina; Sturm, Dominik; Pfaff, Elke; Stark, Sebastian; Hutter, Sonja; Seker-Cin, Huriye; Johann, Pascal; Bender, Sebastian; Schmidt, Christin; Rausch, Tobias; Shih, David; Reimand, Jüri; Sieber, Laura; Wittmann, Andrea; Linke, Linda; Witt, Hendrik; Weber, Ursula D; Zapatka, Marc; König, Rainer; Beroukhim, Rameen; Bergthold, Guillaume; van Sluis, Peter; Volckmann, Richard; Koster, Jan; Versteeg, Rogier; Schmidt, Sabine; Wolf, Stephan; Lawerenz, Chris; Bartholomae, Cynthia C; von Kalle, Christof; Unterberg, Andreas; Herold-Mende, Christel; Hofer, Silvia; Kulozik, Andreas E; von Deimling, Andreas; Scheurlen, Wolfram; Felsberg, Jörg; Reifenberger, Guido

Kool, Marcel; Jones, David T W; Jäger, Natalie; Northcott, Paul A; Pugh, Trevor J; Hovestadt, Volker; Piro, Rosario M; Esparza, L Adriana; Markant, Shirley L; Remke, Marc; Milde, Till; Bourdeaut, Franck; Ryzhova, Marina; Sturm, Dominik; Pfaff, Elke; Stark, Sebastian; Hutter, Sonja; Seker-Cin, Huriye; Johann, Pascal; Bender, Sebastian; Schmidt, Christin; Rausch, Tobias; Shih, David; Reimand, Jüri; Sieber, Laura; Wittmann, Andrea; Linke, Linda; Witt, Hendrik; Weber, Ursula D; Zapatka, Marc; König, Rainer; Beroukhim, Rameen; Bergthold, Guillaume; van Sluis, Peter; Volckmann, Richard; Koster, Jan; Versteeg, Rogier; Schmidt, Sabine; Wolf, Stephan; Lawerenz, Chris; Bartholomae, Cynthia C; von Kalle, Christof; Unterberg, Andreas; Herold-Mende, Christel; Hofer, Silvia; Kulozik, Andreas E; von Deimling, Andreas; Scheurlen, Wolfram; Felsberg, Jörg; Reifenberger, Guido.

Afiliación

Kool M; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany. Electronic address: m.kool@dkfz.de.
Jones DT; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Jäger N; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Northcott PA; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Pugh TJ; Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA.
Hovestadt V; Division of Molecular Genetics, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Piro RM; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Esparza LA; Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
Markant SL; Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
Remke M; The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G 1L7, Canada.
Milde T; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Bourdeaut F; Institut Curie, 75005 Paris, France; Institut Curie/INSERM U830, 75248 Paris, France.
Ryzhova M; Department of Neuropathology, NN Burdenko Neurosurgical Institute, Moscow 125047, Russia.
Sturm D; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Pfaff E; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Stark S; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Hutter S; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Seker-Cin H; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Johann P; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Bender S; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Schmidt C; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Rausch T; European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany.
Shih D; The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G 1L7, Canada.
Reimand J; The Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.
Sieber L; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Wittmann A; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Linke L; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Witt H; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Weber UD; Division of Molecular Genetics, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Zapatka M; Division of Molecular Genetics, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
König R; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany; Leibniz Institute for Natural Product Research and Infection Biology,
Beroukhim R; Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Bergthold G; Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA; UMR 8203, CNRS Vectorology and Anticancer Therapeutics, Gustave Roussy Cancer Institute, University Paris XI, 94805 Villejuif Cedex, France.
van Sluis P; Department of Oncogenomics, Academic Medical Center, Amsterdam 1105 AZ, the Netherlands.
Volckmann R; Department of Oncogenomics, Academic Medical Center, Amsterdam 1105 AZ, the Netherlands.
Koster J; Department of Oncogenomics, Academic Medical Center, Amsterdam 1105 AZ, the Netherlands.
Versteeg R; Department of Oncogenomics, Academic Medical Center, Amsterdam 1105 AZ, the Netherlands.
Schmidt S; Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Wolf S; Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Lawerenz C; Data Management Facility, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Bartholomae CC; Division of Translational Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), 69121 Heidelberg, Germany.
von Kalle C; Division of Translational Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), 69121 Heidelberg, Germany.
Unterberg A; Division of Translational Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), 69121 Heidelberg, Germany.
Herold-Mende C; Division of Translational Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), 69121 Heidelberg, Germany.
Hofer S; Department of Oncology, University Hospital Zürich, 8006 Zürich, Switzerland.
Kulozik AE; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
von Deimling A; Department of Neuropathology, University of Heidelberg, 69120 Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Scheurlen W; Cnopf'sche Kinderklinik, Nürnberg Children's Hospital, 90419 Nürnberg, Germany.
Felsberg J; Department of Neuropathology, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
Reifenberger G; Department of Neuropathology, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.

Cancer Cell ; 25(3): 393-405, 2014 Mar 17.

Article en En | MEDLINE | ID: mdl-24651015

Asunto(s)

Resistencia a Antineoplásicos/genética; Proteínas Hedgehog/genética; Meduloblastoma/genética; Receptores Acoplados a Proteínas G/antagonistas & inhibidores; Receptores Acoplados a Proteínas G/genética; Adolescente; Adulto; Animales; Secuencia de Bases; Compuestos de Bifenilo/uso terapéutico; Neoplasias Cerebelosas/tratamiento farmacológico; Neoplasias Cerebelosas/genética; Niño; Preescolar; ARN Helicasas DEAD-box/genética; Variaciones en el Número de Copia de ADN/genética; Femenino; Perfilación de la Expresión Génica; Secuenciación de Nucleótidos de Alto Rendimiento; Humanos; Lactante; Factores de Transcripción de Tipo Kruppel/genética; Masculino; Meduloblastoma/tratamiento farmacológico; Ratones; Ratones Endogámicos NOD; Ratones SCID; Datos de Secuencia Molecular; Proteína Proto-Oncogénica N-Myc; Trasplante de Neoplasias; Proteínas Nucleares/genética; Proteínas Oncogénicas/genética; Receptores Patched; Receptor Patched-1; Fosfatidilinositol 3-Quinasas/genética; Fosfatidilinositol 3-Quinasas/metabolismo; Regiones Promotoras Genéticas/genética; Proteínas Proto-Oncogénicas c-akt/genética; Proteínas Proto-Oncogénicas c-akt/metabolismo; Piridinas/uso terapéutico; Receptores de Superficie Celular/genética; Proteínas Represoras/genética; Transducción de Señal/genética; Receptor Smoothened; Telomerasa/genética; Proteína p53 Supresora de Tumor/genética; Adulto Joven; Proteína Gli2 con Dedos de Zinc

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Resistencia a Antineoplásicos / Receptores Acoplados a Proteínas G / Proteínas Hedgehog / Meduloblastoma Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2014 Tipo del documento: Article

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