Sustained Effectiveness of Monovalent and Pentavalent Rotavirus Vaccines in Children.
J Pediatr
; 172: 116-120.e1, 2016 05.
Article
en En
| MEDLINE
| ID: mdl-26935786
ABSTRACT
OBJECTIVE:
Using case-control methodology, we measured the vaccine effectiveness (VE) of the 2-dose monovalent rotavirus vaccine (RV1) and 3-dose pentavalent rotavirus vaccine (RV5) series given in infancy against rotavirus disease resulting in hospital emergency department or inpatient care. STUDYDESIGN:
Children were eligible for enrollment if they presented to any 1 of 3 hospitals in Atlanta, Georgia with diarrhea ≤10 days duration during January-June 2013 and were born after RV1 introduction. Stool samples were tested for rotavirus by enzyme immunoassay and immunization records were obtained from providers and the state electronic immunization information system. Case-subjects (children testing rotavirus antigen-positive) were compared with children testing rotavirus antigen-negative.RESULTS:
Overall, 98 rotavirus-case subjects and 175 rotavirus-negative controls were enrolled. Genotype G12P[8] predominated (n = 87, 89%). The VE of 2 RV1 doses was 84% (95% CI 38, 96) among children aged 8-23 months and 82% (95% CI 41, 95) among children aged ≥24 months. For the same age groups, the VE of 3 RV5 doses was 80% (95% CI 27, 95) and 87% (95% CI 22, 98), respectively.CONCLUSIONS:
Under routine use, the RV1 and RV5 series were both effective against moderate-to-severe rotavirus disease during a G12P[8] season, and both vaccines demonstrated sustained protection beyond the first 2 years of life.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Infecciones por Rotavirus
/
Rotavirus
/
Vacunas contra Rotavirus
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Gastroenteritis
Tipo de estudio:
Observational_studies
Límite:
Child
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Child, preschool
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Female
/
Humans
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Infant
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Male
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Pediatr
Año:
2016
Tipo del documento:
Article