Clopidogrel treatment may associate with worsening of endothelial function and development of new digital ulcers in patients with systemic sclerosis: results from an open label, proof of concept study.

Ntelis, Konstantinos; Gkizas, Vasileios; Filippopoulou, Alexandra; Davlouros, Periclis; Alexopoulos, Dimitrios; Andonopoulos, Andrew P; Daoussis, Dimitrios

Ntelis, Konstantinos; Gkizas, Vasileios; Filippopoulou, Alexandra; Davlouros, Periclis; Alexopoulos, Dimitrios; Andonopoulos, Andrew P; Daoussis, Dimitrios.

Afiliación

Ntelis K; Division of Rheumatology, Department of Internal Medicine, Patras University Hospital, University of Patras Medical School, 26504, Rion, Patras, Greece. kosdelis@gmail.com.
Gkizas V; Department of Cardiology, Patras University Hospital, University of Patras Medical School, 26504, Rion, Patras, Greece.
Filippopoulou A; Division of Rheumatology, Department of Internal Medicine, Patras University Hospital, University of Patras Medical School, 26504, Rion, Patras, Greece.
Davlouros P; Department of Cardiology, Patras University Hospital, University of Patras Medical School, 26504, Rion, Patras, Greece.
Alexopoulos D; Department of Cardiology, Patras University Hospital, University of Patras Medical School, 26504, Rion, Patras, Greece.
Andonopoulos AP; Division of Rheumatology, Department of Internal Medicine, Patras University Hospital, University of Patras Medical School, 26504, Rion, Patras, Greece.
Daoussis D; Division of Rheumatology, Department of Internal Medicine, Patras University Hospital, University of Patras Medical School, 26504, Rion, Patras, Greece.

BMC Musculoskelet Disord ; 17: 213, 2016 05 17.

Article en En | MEDLINE | ID: mdl-27188755

Asunto(s)

Endotelio Vascular/efectos de los fármacos; Activación Plaquetaria/efectos de los fármacos; Inhibidores de Agregación Plaquetaria/efectos adversos; Antagonistas del Receptor Purinérgico P2Y/efectos adversos; Esclerodermia Sistémica/tratamiento farmacológico; Úlcera Cutánea/inducido químicamente; Ticlopidina/análogos & derivados; Adenosina Difosfato/metabolismo; Adulto; Anciano; Anciano de 80 o más Años; Animales; Clopidogrel; Endotelio Vascular/metabolismo; Femenino; Dedos/patología; Humanos; Masculino; Persona de Mediana Edad; Inhibidores de Agregación Plaquetaria/uso terapéutico; Prueba de Estudio Conceptual; Antagonistas del Receptor Purinérgico P2Y/uso terapéutico; Esclerodermia Sistémica/sangre; Serotonina/sangre; Ticlopidina/efectos adversos; Ticlopidina/uso terapéutico; Molécula 1 de Adhesión Celular Vascular/sangre

Palabras clave

Clopidogrel; Digital ulcers; Platelets; Scleroderma; Systemic sclerosis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Esclerodermia Sistémica / Úlcera Cutánea / Ticlopidina / Endotelio Vascular / Inhibidores de Agregación Plaquetaria / Activación Plaquetaria / Antagonistas del Receptor Purinérgico P2Y Tipo de estudio: Risk_factors_studies Límite: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Musculoskelet Disord Asunto de la revista: FISIOLOGIA / ORTOPEDIA Año: 2016 Tipo del documento: Article País de afiliación: Grecia

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