Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans.

Rieckher, Matthias; Markaki, Maria; Princz, Andrea; Schumacher, Björn; Tavernarakis, Nektarios

Rieckher, Matthias; Markaki, Maria; Princz, Andrea; Schumacher, Björn; Tavernarakis, Nektarios.

Afiliación

Rieckher M; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, Heraklion 71110, Greece; Institute for Genome Stability in Ageing and Disease, Cologne Cluster of Excellence in Cellular Stress Responses in Aging-Associated Diseases (CECAD), University Hospital Colog
Markaki M; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, Heraklion 71110, Greece.
Princz A; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, Heraklion 71110, Greece.
Schumacher B; Institute for Genome Stability in Ageing and Disease, Cologne Cluster of Excellence in Cellular Stress Responses in Aging-Associated Diseases (CECAD), University Hospital Cologne, 50931 Cologne, Germany.
Tavernarakis N; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, Heraklion 71110, Greece; Department of Basic Sciences, School of Medicine, University of Crete, Heraklion 71110, Greece. Electronic address: tavernarakis@imbb.forth.gr.

Cell Rep ; 25(1): 199-211.e6, 2018 10 02.

Article en En | MEDLINE | ID: mdl-30282029

Asunto(s)

Proteínas de Caenorhabditis elegans/metabolismo; Caenorhabditis elegans/metabolismo; Factor 4E Eucariótico de Iniciación/metabolismo; Animales; Caenorhabditis elegans/genética; Proteínas de Caenorhabditis elegans/biosíntesis; Regulación hacia Abajo; Factor 4E Eucariótico de Iniciación/genética; Redes Reguladoras de Genes; Longevidad; Biosíntesis de Proteínas; Isoformas de Proteínas; Proteostasis; ARN Mensajero/genética; ARN Mensajero/metabolismo; Estrés Fisiológico

Palabras clave

aging; eukaryotic initiation factor 4E; mRNA decapping; mRNA translation; processing bodies; protein synthesis; proteostasis; stress response

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Caenorhabditis elegans / Proteínas de Caenorhabditis elegans / Factor 4E Eucariótico de Iniciación Límite: Animals Idioma: En Revista: Cell Rep Año: 2018 Tipo del documento: Article

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