A close look onto structural models and primary ligands of metallo-ß-lactamases.

Raczynska, Joanna E; Shabalin, Ivan G; Minor, Wladek; Wlodawer, Alexander; Jaskolski, Mariusz

Raczynska, Joanna E; Shabalin, Ivan G; Minor, Wladek; Wlodawer, Alexander; Jaskolski, Mariusz.

Afiliación

Raczynska JE; Center for Biocrystallographic Research, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Shabalin IG; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA; Center for Structural Genomics of Infectious Diseases, Charlottesville, VA 22908, USA.
Minor W; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA; Center for Structural Genomics of Infectious Diseases, Charlottesville, VA 22908, USA.
Wlodawer A; Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD 21702, USA.
Jaskolski M; Center for Biocrystallographic Research, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland; Department of Crystallography, Faculty of Chemistry, A. Mickiewicz University, Poznan, Poland. Electronic address: mariuszj@amu.edu.pl.

Drug Resist Updat ; 40: 1-12, 2018 09.

Article en En | MEDLINE | ID: mdl-30466711

Asunto(s)

Modelos Estructurales; Inhibidores de beta-Lactamasas/química; beta-Lactamasas/química; beta-Lactamas/química; Investigación Biomédica; Cristalografía por Rayos X; Ligandos; Modelos Moleculares; Estructura Molecular; Conformación Proteica; Especificidad por Sustrato; Inhibidores de beta-Lactamasas/farmacología; beta-Lactamas/farmacología

Palabras clave

Antibiotic resistance; Data mining; Drug design target; Metal coordination; Metallo-ß-Lactamase; Model validation; New Delhi metallo-ß-lactamase (NDM); Protein Data Bank (PDB); Reproducibility; Structural databases; Structure re-deposition

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Beta-Lactamasas / Beta-Lactamas / Inhibidores de beta-Lactamasas / Modelos Estructurales Idioma: En Revista: Drug Resist Updat Asunto de la revista: ANTINEOPLASICOS Año: 2018 Tipo del documento: Article País de afiliación: Polonia

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