Inhibition of LSD1 by small molecule inhibitors stimulates fetal hemoglobin synthesis.

Le, Cuong Quang; Myers, Greggory; Habara, Alawi; Jearawiriyapaisarn, Natee; Murphy, George J; Chui, David H K; Steinberg, Martin H; Engel, James Douglas; Cui, Shuaiying

Le, Cuong Quang; Myers, Greggory; Habara, Alawi; Jearawiriyapaisarn, Natee; Murphy, George J; Chui, David H K; Steinberg, Martin H; Engel, James Douglas; Cui, Shuaiying.

Afiliación

Le CQ; Section of Hematology-Medical Oncology, Department of Medicine, Boston University School of Medicine, Boston, MA.
Myers G; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI.
Habara A; Section of Hematology-Medical Oncology, Department of Medicine, Boston University School of Medicine, Boston, MA.
Jearawiriyapaisarn N; Department of Biochemistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Murphy GJ; Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Salaya, Thailand; and.
Chui DHK; Section of Hematology-Medical Oncology, Department of Medicine, Boston University School of Medicine, Boston, MA.
Steinberg MH; Center for Regenerative Medicine, Boston University, Boston Medical Center, Boston, MA.
Engel JD; Section of Hematology-Medical Oncology, Department of Medicine, Boston University School of Medicine, Boston, MA.
Cui S; Section of Hematology-Medical Oncology, Department of Medicine, Boston University School of Medicine, Boston, MA.

Blood ; 133(22): 2455-2459, 2019 05 30.

Article en En | MEDLINE | ID: mdl-30992270

Asunto(s)

Anemia de Células Falciformes/tratamiento farmacológico; Inhibidores Enzimáticos/farmacología; Células Eritroides/metabolismo; Hemoglobina Fetal/biosíntesis; Histona Demetilasas/antagonistas & inhibidores; Células Madre Pluripotentes Inducidas/metabolismo; Anemia de Células Falciformes/metabolismo; Anemia de Células Falciformes/patología; Animales; Inhibidores Enzimáticos/química; Células Eritroides/patología; Histona Demetilasas/metabolismo; Humanos; Células Madre Pluripotentes Inducidas/patología; Ratones

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Hemoglobina Fetal / Células Eritroides / Inhibidores Enzimáticos / Células Madre Pluripotentes Inducidas / Histona Demetilasas / Anemia de Células Falciformes Límite: Animals / Humans Idioma: En Revista: Blood Año: 2019 Tipo del documento: Article País de afiliación: Marruecos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google