Circulating endothelial cells in Behçet's disease: is there a relationship with vascular involvement?
Clin Exp Rheumatol
; 37 Suppl 121(6): 105-110, 2019.
Article
en En
| MEDLINE
| ID: mdl-31856936
ABSTRACT
OBJECTIVES:
Circulating endothelial cells (CEC) are identified in conditions with vascular damage such as systemic vasculitis. Our aim was to investigate if EPC, CEC, and/or its subgroups activated CEC (aCEC) or resting CEC (rCEC) related with vascular involvement in Behçet's disease (BD).METHODS:
In total 60 patients were included in this study, divided into 4 groups 1) Behçet patients with a history of vascular involvement vascular BD; 2) Behçet patients with mucocutaneus involvement mucocutaneus BD; 3) patients with history of thrombosis due to other causes thrombosis; 4) 20 healthy controls were also included control group. Percentages of CEC, aCEC, rCEC and EPCs in peripheral blood mononuclear cells were measured by flow cytometry.RESULTS:
CEC (3.75 (1.80-7.20), 1.80 (0.70-3.53), 3.50 (1.83-7.23), 2.45 (1.28- 4.60)) and aCEC (2.40 (1.28-4.28), 1.10 (0.77-2.20), 3.15 (1.48-7.20), 3.20 (1.15-9.80) levels were did not show a statistically significant difference between groups (p0.077 and p0.054, respectively). EPC and rCEC levels were higher in vascular BD and thrombosis groups than mucocutaneus BD and control groups (EPC10.5 (7.20-18.3), 11.6 (7.30-20.9) vs. 7.15 (5.55-8.25), 10.2 (5.93-18.6), rCEC 5.35 (3.13-7.90), 6.45 (4.60-10.8) vs. 4.95 (3.05-7.55), 3.40 (1.88-4.30), p0.042 and p0.007, respectively).CONCLUSIONS:
CEC, EPC, aCEC and rCEC may have role in the assessment of vascular involvement in BD. Longitudinal studies would be needed to identify the utility of these cells for the follow up and risk stratification of BD patients with vascular involvement for recurrences or identify BD patients at risk of vascular involvement.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Síndrome de Behçet
/
Células Endoteliales
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Clin Exp Rheumatol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Turquía