Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth.

Li, Xue; Kong, Lingmei; Yang, Qihong; Duan, Aizhu; Ju, Xiaoman; Cai, Bicheng; Chen, Lin; An, Tao; Li, Yan

Li, Xue; Kong, Lingmei; Yang, Qihong; Duan, Aizhu; Ju, Xiaoman; Cai, Bicheng; Chen, Lin; An, Tao; Li, Yan.

Afiliación

Li X; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Kong L; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Yang Q; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Duan A; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Ju X; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Cai B; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Chen L; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
An T; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic
Li Y; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic

J Biol Chem ; 295(11): 3576-3589, 2020 03 13.

Article en En | MEDLINE | ID: mdl-32029476

Asunto(s)

Neoplasias Colorrectales/enzimología; Neoplasias Colorrectales/patología; Sesquiterpenos/farmacología; Peptidasa Específica de Ubiquitina 7/antagonistas & inhibidores; Vía de Señalización Wnt/efectos de los fármacos; 4-Butirolactona/análogos & derivados; 4-Butirolactona/química; 4-Butirolactona/farmacología; Apoptosis/efectos de los fármacos; Ciclo Celular/efectos de los fármacos; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Neoplasias Colorrectales/genética; Regulación hacia Abajo/efectos de los fármacos; Inhibidores Enzimáticos/farmacología; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Células HEK293; Humanos; Proteolisis/efectos de los fármacos; Sesquiterpenos/química; Peptidasa Específica de Ubiquitina 7/metabolismo; Ubiquitinación/efectos de los fármacos; beta Catenina/metabolismo

Palabras clave

USP7; Wnt signaling; colorectal cancer; deubiquitinating activity; deubiquitylation (deubiquitination); enzyme inhibitor; parthenolide; pharmacology; proteasome system; protein homeostasis; small molecule; ubiquitin-specific peptidase 7; ubiquitination; ß-catenin

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sesquiterpenos / Neoplasias Colorrectales / Vía de Señalización Wnt / Peptidasa Específica de Ubiquitina 7 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article País de afiliación: China

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