Repetitive RNAs as Regulators of Chromatin-Associated Subcompartment Formation by Phase Separation.
J Mol Biol
; 432(15): 4270-4286, 2020 07 10.
Article
en En
| MEDLINE
| ID: mdl-32320688
ABSTRACT
Repetitive RNA (repRNA) sequences emerge as important regulators of the dynamic organization of genomic loci into membrane-less subcompartments with distinct nuclear functions. These domains include sites of active transcription like the nucleolus as well as (peri)centromeric and telomeric satellite repeats. Recent studies point to an important role of repRNAs in complex with proteins to promote a phase separation-driven formation of chromatin domains. We review how key features of the phase separation process can be revealed by different experimental approaches and discuss the associated structure-function relationships for chromatin subcompartments that involve repRNA.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
ARN
/
Cromatina
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Mol Biol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Alemania