Oridonin induces the apoptosis of mucoepidermoid carcinoma cell lines in a myeloid cell leukemia1dependent manner.
Int J Oncol
; 57(1): 377-385, 2020 07.
Article
en En
| MEDLINE
| ID: mdl-32467983
ABSTRACT
Oridonin, an active diterpenoid isolated from Rabdosia rubescens, has been reported to exhibit anticancer activities in several tumors. The aim of the present study was to investigate the anticancer effects and molecular mechanisms of oridonin in mucoepidermoid carcinoma (MEC). Treatment with oridonin induced the apoptosis of MC3 and YD15 cell and inhibited the expression of myeloid cell leukemia1 (MCL1) through the regulation of the protein level through posttranslational regulation in these cell lines. Oridonin significantly increased the expression level of truncated Bid (tBid) as a downstream target of MCL1 and subsequently decreased the mitochondrial membrane potential. The ectopic expression of MCL1 protein was sufficient to reverse the induction of apoptosis and the increased tBid expression induced by oridonin in both cell lines. Taken together, these results suggest that oridonin exerts an apoptotic effect through the modulation of MCL1 and tBid in human MEC cell lines and may thus be a potential anticancer drug candidate for the treatment of human MEC.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Apoptosis
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Carcinoma Mucoepidermoide
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Diterpenos de Tipo Kaurano
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Proteína 1 de la Secuencia de Leucemia de Células Mieloides
/
Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Revista:
Int J Oncol
Asunto de la revista:
NEOPLASIAS
Año:
2020
Tipo del documento:
Article