Mutations Identified in the Hepatitis C Virus (HCV) Polymerase of Patients with Chronic HCV Treated with Ribavirin Cause Resistance and Affect Viral Replication Fidelity.

Mejer, Niels; Fahnøe, Ulrik; Galli, Andrea; Ramirez, Santseharay; Weiland, Ola; Benfield, Thomas; Bukh, Jens

Mejer, Niels; Fahnøe, Ulrik; Galli, Andrea; Ramirez, Santseharay; Weiland, Ola; Benfield, Thomas; Bukh, Jens.

Afiliación

Mejer N; Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Fahnøe U; Department of Infectious Diseases, Hvidovre Hospital, Hvidovre, Denmark.
Galli A; Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ramirez S; Department of Infectious Diseases, Hvidovre Hospital, Hvidovre, Denmark.
Weiland O; Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Benfield T; Department of Infectious Diseases, Hvidovre Hospital, Hvidovre, Denmark.
Bukh J; Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Antimicrob Agents Chemother ; 64(12)2020 11 17.

Article en En | MEDLINE | ID: mdl-32928732

Asunto(s)

Hepatitis C Crónica; Hepatitis C; Antivirales/farmacología; Antivirales/uso terapéutico; Farmacorresistencia Viral/genética; Hepacivirus/genética; Hepatitis C/tratamiento farmacológico; Hepatitis C Crónica/tratamiento farmacológico; Humanos; Mutación; Ribavirina/farmacología; Ribavirina/uso terapéutico; Proteínas no Estructurales Virales/genética; Replicación Viral

Palabras clave

HCV; NS5B polymerase; hepatitis; hepatitis C virus; mutagenesis; resistance; ribavirin

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Hepatitis C / Hepatitis C Crónica Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2020 Tipo del documento: Article País de afiliación: Dinamarca

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