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Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation.
Zhu, Guangya; Xie, Jingjing; Kong, Wenna; Xie, Jingfei; Li, Yichen; Du, Lin; Zheng, Qiangang; Sun, Lin; Guan, Mingfeng; Li, Huan; Zhu, Tianxin; He, Hao; Liu, Zhenying; Xia, Xi; Kan, Chen; Tao, Youqi; Shen, Hong C; Li, Dan; Wang, Siying; Yu, Yongguo; Yu, Zhi-Hong; Zhang, Zhong-Yin; Liu, Cong; Zhu, Jidong.
Afiliación
  • Zhu G; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201203, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
  • Xie J; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201203, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
  • Kong W; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201203, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
  • Xie J; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201203, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
  • Li Y; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China.
  • Du L; Etern Biopharma Co. Ltd., Shanghai 201203, China.
  • Zheng Q; Etern Biopharma Co. Ltd., Shanghai 201203, China.
  • Sun L; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201203, China.
  • Guan M; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201203, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
  • Li H; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201203, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
  • Zhu T; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201203, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
  • He H; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201203, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
  • Liu Z; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201203, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
  • Xia X; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201203, China.
  • Kan C; Department of Pathophysiology, Anhui Medical University, Hefei 230032, China.
  • Tao Y; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China.
  • Shen HC; Roche Innovation Center Shanghai, Roche Pharma Research & Early Development, Shanghai 201203, China.
  • Li D; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China.
  • Wang S; Department of Pathophysiology, Anhui Medical University, Hefei 230032, China.
  • Yu Y; Department of Pediatric Endocrinology and Genetics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute for Pediatric Research, Shanghai 200092, China.
  • Yu ZH; Department of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research and Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA.
  • Zhang ZY; Department of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research and Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA.
  • Liu C; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: liulab@sioc.ac.cn.
  • Zhu J; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201203, China; Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China. Electr
Cell ; 183(2): 490-502.e18, 2020 10 15.
Article en En | MEDLINE | ID: mdl-33002410
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Quinasas Activadas por Mitógenos / Proteína Tirosina Fosfatasa no Receptora Tipo 11 Tipo de estudio: Risk_factors_studies Límite: Animals / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Cell Año: 2020 Tipo del documento: Article País de afiliación: China
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Quinasas Activadas por Mitógenos / Proteína Tirosina Fosfatasa no Receptora Tipo 11 Tipo de estudio: Risk_factors_studies Límite: Animals / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Cell Año: 2020 Tipo del documento: Article País de afiliación: China