MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer.

Suarez-Lopez, Lucia; Kong, Yi Wen; Sriram, Ganapathy; Patterson, Jesse C; Rosenberg, Samantha; Morandell, Sandra; Haigis, Kevin M; Yaffe, Michael B

Suarez-Lopez, Lucia; Kong, Yi Wen; Sriram, Ganapathy; Patterson, Jesse C; Rosenberg, Samantha; Morandell, Sandra; Haigis, Kevin M; Yaffe, Michael B.

Afiliación

Suarez-Lopez L; Center for Precision Cancer Medicine, Koch Institute for Integrated Cancer Research and Departments of Biological Engineering and Biology, Massachusetts Institute of Technology, Cambridge, MA, United States.
Kong YW; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, United States.
Sriram G; Center for Precision Cancer Medicine, Koch Institute for Integrated Cancer Research and Departments of Biological Engineering and Biology, Massachusetts Institute of Technology, Cambridge, MA, United States.
Patterson JC; Center for Precision Cancer Medicine, Koch Institute for Integrated Cancer Research and Departments of Biological Engineering and Biology, Massachusetts Institute of Technology, Cambridge, MA, United States.
Rosenberg S; Center for Precision Cancer Medicine, Koch Institute for Integrated Cancer Research and Departments of Biological Engineering and Biology, Massachusetts Institute of Technology, Cambridge, MA, United States.
Morandell S; Center for Precision Cancer Medicine, Koch Institute for Integrated Cancer Research and Departments of Biological Engineering and Biology, Massachusetts Institute of Technology, Cambridge, MA, United States.
Haigis KM; Center for Precision Cancer Medicine, Koch Institute for Integrated Cancer Research and Departments of Biological Engineering and Biology, Massachusetts Institute of Technology, Cambridge, MA, United States.
Yaffe MB; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, United States.

Front Immunol ; 11: 607891, 2020.

Article en En | MEDLINE | ID: mdl-33708191

Asunto(s)

Proteínas Angiogénicas/metabolismo; Neoplasias Asociadas a Colitis/enzimología; Péptidos y Proteínas de Señalización Intracelular/metabolismo; Neovascularización Patológica; Proteínas Serina-Treonina Quinasas/metabolismo; Macrófagos Asociados a Tumores/enzimología; Traslado Adoptivo; Proteínas Angiogénicas/genética; Animales; Células Cultivadas; Neoplasias Asociadas a Colitis/genética; Neoplasias Asociadas a Colitis/patología; Modelos Animales de Enfermedad; Progresión de la Enfermedad; Regulación Neoplásica de la Expresión Génica; Péptidos y Proteínas de Señalización Intracelular/genética; Masculino; Ratones Endogámicos C57BL; Ratones Noqueados; Fenotipo; Proteínas Serina-Treonina Quinasas/genética; Transducción de Señal; Transcripción Genética; Microambiente Tumoral; Macrófagos Asociados a Tumores/trasplante

Palabras clave

MAPKAP kinase 2; angiogenesis; colon tumors; inflammation driven tumorigenesis; signal transduction; stress signaling; tumor associated macrophage (TAM)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Serina-Treonina Quinasas / Proteínas Angiogénicas / Péptidos y Proteínas de Señalización Intracelular / Neoplasias Asociadas a Colitis / Macrófagos Asociados a Tumores / Neovascularización Patológica Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Front Immunol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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