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Epstein-Barr virus (EBV) deletions as biomarkers of response to treatment of chronic active EBV.
Venturini, Cristina; Houldcroft, Charlotte J; Lazareva, Arina; Wegner, Fanny; Morfopoulou, Sofia; Amrolia, Persis J; Golwala, Zainab; Rao, Anupama; Marks, Stephen D; Simmonds, Jacob; Yoshikawa, Tetsushi; Farrell, Paul J; Cohen, Jeffrey I; Worth, Austen J; Breuer, Judith.
Afiliación
  • Venturini C; Institute of Child Health, University College London, London, UK.
  • Houldcroft CJ; Department of Medicine, University of Cambridge, Cambridge, UK.
  • Lazareva A; Bone Marrow Transplantation Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
  • Wegner F; Applied Microbiology Research, Department of Biomedicine, University of Basel, Switzerland.
  • Morfopoulou S; Clinical Bacteriology and Mycology, University Hospital Basel, Basel, Switzerland.
  • Amrolia PJ; Institute of Child Health, University College London, London, UK.
  • Golwala Z; Bone Marrow Transplantation Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
  • Rao A; Great Ormond Street Hospital for Children NHS Foundation Trust, UK.
  • Marks SD; Great Ormond Street Hospital for Children NHS Foundation Trust, UK.
  • Simmonds J; Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, UK.
  • Yoshikawa T; NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London Great Ormond Street Institute of Child Health, London, UK.
  • Farrell PJ; Great Ormond Street Hospital for Children NHS Foundation Trust, UK.
  • Cohen JI; Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.
  • Worth AJ; Section of Virology, Department of Infectious Disease, Imperial College Faculty of Medicine, London, UK.
  • Breuer J; Laboratory of Infectious Disease, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
Br J Haematol ; 195(2): 249-255, 2021 10.
Article en En | MEDLINE | ID: mdl-34431085
ABSTRACT
Chronic active Epstein-Barr virus (CAEBV) disease is a rare condition characterised by persistent EBV infection in previously healthy individuals. Defective EBV genomes were found in East Asian patients with CAEBV. In the present study, we sequenced 14 blood EBV samples from three UK patients with CAEBV, comparing the results with saliva CAEBV samples and other conditions. We observed EBV deletions in blood, some of which may disrupt viral replication, but not saliva in CAEBV. Deletions were lost overtime after successful treatment. These findings are compatible with CAEBV being associated with the evolution and persistence of EBV+ haematological clones that are lost on successful treatment.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Saliva / Eliminación de Secuencia / Herpesvirus Humano 4 / Infecciones por Virus de Epstein-Barr Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Br J Haematol Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Saliva / Eliminación de Secuencia / Herpesvirus Humano 4 / Infecciones por Virus de Epstein-Barr Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Br J Haematol Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido