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Theranostic Platforms Based on Silica and Magnetic Nanoparticles Containing Quinacrine, Chitosan, Fluorophores, and Quantum Dots.
Korolev, Dmitry V; Shulmeyster, Galina A; Evreinova, Natalia V; Syrovatkina, Maria S; Istomina, Maria S; Postnov, Victor N; Aleksandrov, Ilia V; Krasichkov, Aleksandr S; Galagudza, Michael M.
Afiliación
  • Korolev DV; Institute of Experimental Medicine, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 Saint Petersburg, Russia.
  • Shulmeyster GA; Laboratory of Biophysics of Blood Circulation, Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo Street, 197022 Saint Petersburg, Russia.
  • Evreinova NV; Institute of Experimental Medicine, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 Saint Petersburg, Russia.
  • Syrovatkina MS; Institute of Experimental Medicine, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 Saint Petersburg, Russia.
  • Istomina MS; Department of Electrochemical Production, St. Petersburg State Technological Institute Technical University, 26 Moskovsky pr., 198003 Saint Petersburg, Russia.
  • Postnov VN; Department of Micro- and Nanoelectronics, Saint Petersburg Electrotechnical University "LETI", 5 Professora Popova Street, 197376 Saint Petersburg, Russia.
  • Aleksandrov IV; Institute of Experimental Medicine, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 Saint Petersburg, Russia.
  • Krasichkov AS; Department of Micro- and Nanoelectronics, Saint Petersburg Electrotechnical University "LETI", 5 Professora Popova Street, 197376 Saint Petersburg, Russia.
  • Galagudza MM; Institute of Experimental Medicine, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 Saint Petersburg, Russia.
Int J Mol Sci ; 23(2)2022 Jan 15.
Article en En | MEDLINE | ID: mdl-35055120
ABSTRACT
In this paper, we describe the synthesis of multilayer nanoparticles as a platform for the diagnosis and treatment of ischemic injuries. The platform is based on magnetite (MNP) and silica (SNP) nanoparticles, while quinacrine is used as an anti-ischemic agent. The synthesis includes the surface modification of nanoparticles with (3-glycidyloxypropyl)trimethoxysilane (GPMS), the immobilization of quinacrine, and the formation of a chitosan coating, which is used to fix the fluorophore indocyanine green (ICG) and colloidal quantum dots AgInS2/ZnS (CQDs), which serve as secondary radiation sources. The potential theranostic platform was studied in laboratory animals.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Quinacrina / Dióxido de Silicio / Puntos Cuánticos / Isquemia Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Rusia
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Quinacrina / Dióxido de Silicio / Puntos Cuánticos / Isquemia Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Rusia