Protection against glutathione depletion-associated oxidative neuronal death by neurotransmitters norepinephrine and dopamine: Protein disulfide isomerase as a mechanistic target for neuroprotection.

Choi, Hye Joung; Chen, Tong-Xiang; Hou, Ming-Jie; Song, Ji Hoon; Li, Peng; Liu, Chun-Feng; Wang, Pan; Zhu, Bao Ting

Choi, Hye Joung; Chen, Tong-Xiang; Hou, Ming-Jie; Song, Ji Hoon; Li, Peng; Liu, Chun-Feng; Wang, Pan; Zhu, Bao Ting.

Afiliación

Choi HJ; Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong, Shenzhen, 518172, China.
Chen TX; Department of Pharmacology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Hou MJ; Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong, Shenzhen, 518172, China.
Song JH; Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong, Shenzhen, 518172, China.
Li P; Department of Pharmacology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Liu CF; Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong, Shenzhen, 518172, China.
Wang P; Institute of Neuroscience, Soochow University, and Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Zhu BT; Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong, Shenzhen, 518172, China.

Acta Pharmacol Sin ; 43(10): 2527-2541, 2022 Oct.

Article en En | MEDLINE | ID: mdl-35347247

Asunto(s)

Muerte Celular; Dopamina; Neuroprotección; Norepinefrina; Proteína Disulfuro Isomerasas; Acetilcolina/farmacología; Adenosina Trifosfato/metabolismo; Animales; Muerte Celular/efectos de los fármacos; Dopamina/farmacología; Ácido Glutámico/metabolismo; Glutatión/metabolismo; Glicina/farmacología; Histamina/metabolismo; Ratones; Simulación del Acoplamiento Molecular; Neuroprotección/efectos de los fármacos; Neurotransmisores; Óxido Nítrico Sintasa de Tipo I/metabolismo; Norepinefrina/farmacología; Estrés Oxidativo; Proteína Disulfuro Isomerasas/efectos de los fármacos; Proteína Disulfuro Isomerasas/metabolismo; Serotonina/metabolismo; Serotonina/farmacología; Superóxidos/metabolismo; Superóxidos/farmacología; Proteína p53 Supresora de Tumor/metabolismo; Ácido gamma-Aminobutírico/metabolismo

Palabras clave

MAPKsâp53âGADD45α; dopamine; glutamate; glutathione; norepinephrine; oxidative neurodegeneration

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Dopamina / Norepinefrina / Muerte Celular / Proteína Disulfuro Isomerasas / Neuroprotección Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Acta Pharmacol Sin Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China

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