Mutant p53 achieved Gain-of-Function by promoting tumor growth and immune escape through PHLPP2/AKT/PD-L1 pathway.

Liu, Nannan; Jiang, Xinxiu; Guo, Leiming; Zhang, Chuchu; Jiang, Meimei; Sun, Zhuoran; Zhang, Yizheng; Mi, Wunan; Li, Jiehan; Fu, Yang; Wang, Feng; Zhang, Lingling; Zhang, Yingjie

Liu, Nannan; Jiang, Xinxiu; Guo, Leiming; Zhang, Chuchu; Jiang, Meimei; Sun, Zhuoran; Zhang, Yizheng; Mi, Wunan; Li, Jiehan; Fu, Yang; Wang, Feng; Zhang, Lingling; Zhang, Yingjie.

Afiliación

Liu N; School of Biomedical Sciences, Hunan University, Changsha, China.
Jiang X; School of Biomedical Sciences, Hunan University, Changsha, China.
Guo L; Department of Laboratory Medicine, the Third Xiangya Hospital, Central South University, Changsha, China.
Zhang C; Department of Gastroenterology, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Jiang M; Department of R&D, Shanghai Creative Immune Therapeutics Co., Ltd, Shanghai, China.
Sun Z; School of Biomedical Sciences, Hunan University, Changsha, China.
Zhang Y; School of Biomedical Sciences, Hunan University, Changsha, China.
Mi W; Department of Laboratory Medicine, the Third Xiangya Hospital, Central South University, Changsha, China.
Li J; School of Biomedical Sciences, Hunan University, Changsha, China.
Fu Y; Department of Gastroenterology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Wang F; School of Biomedical Sciences, Hunan University, Changsha, China.
Zhang L; Department of Gastroenterology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Zhang Y; School of Biomedical Sciences, Hunan University, Changsha, China.

Int J Biol Sci ; 18(6): 2419-2438, 2022.

Article en En | MEDLINE | ID: mdl-35414774

Asunto(s)

Antígeno B7-H1; Proteínas Proto-Oncogénicas c-akt; Antígeno B7-H1/genética; Antígeno B7-H1/metabolismo; Línea Celular Tumoral; Mutación con Ganancia de Función; Genes p53; Humanos; Fosfoproteínas Fosfatasas/genética; Fosfoproteínas Fosfatasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/genética; Proteínas Proto-Oncogénicas c-akt/metabolismo; Proteína p53 Supresora de Tumor/genética

Palabras clave

AKT; PD-L1; PHLPP2; immunity; mutant TP53

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas c-akt / Antígeno B7-H1 Límite: Humans Idioma: En Revista: Int J Biol Sci Asunto de la revista: BIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China

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