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Current Status and Future Prospects of Inflammatory Bowel Disease Genetics.
Kakuta, Yoichi; Naito, Takeo; Kinouchi, Yoshitaka; Masamune, Atsushi.
Afiliación
  • Kakuta Y; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Naito T; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Kinouchi Y; Student Healthcare Center, Institute for Excellence in Higher Education, Tohoku University, Sendai, Japan.
  • Masamune A; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Digestion ; 104(1): 7-15, 2023.
Article en En | MEDLINE | ID: mdl-36323245
ABSTRACT

BACKGROUND:

The genetic background of inflammatory bowel diseases (IBDs) has been explored using genetic analysis techniques, such as genome-wide association studies for the population and whole-exome sequencing analyses of family lineages in cases of very early onset.

SUMMARY:

The results of genetic analysis for IBD indicated the involvement of innate and adaptive immune system variations and epithelial abnormalities in the pathogenesis of IBD. Several associated genes were also reported, indicating that IBD occurs in a heterogeneous population with an extremely diverse background. The genetic background of IBDs is currently being studied to understand not only its onset but also its prognosis, response to treatment, and adverse effects. In the future, it will be possible to use an individual's genetic information for determining appropriate treatment. In Japan, the NUDT15 polymorphism test is performed before administering thiopurine preparations. However, because of racial differences in genetic analysis, biased analysis toward some racial groups may result in overlooking important genetic backgrounds of IBD. KEY MESSAGE Studies of IBDs in a more diverse range of races are expected to elucidate genetic factors through a transethnic analysis, thereby aiding the development of novel treatments and precision medicine for IBDs.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Estudio de Asociación del Genoma Completo Tipo de estudio: Prognostic_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Digestion Año: 2023 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Estudio de Asociación del Genoma Completo Tipo de estudio: Prognostic_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Digestion Año: 2023 Tipo del documento: Article País de afiliación: Japón