Directed natural evolution generates a next-generation oncolytic virus with a high potency and safety profile.

Guo, Li; Hu, Cheng; Liu, Yang; Chen, Xiaoyu; Song, Deli; Shen, Runling; Liu, Zhanzhen; Jia, Xudong; Zhang, Qinfen; Gao, Yuanzhu; Deng, Zhezhi; Zuo, Tao; Hu, Jun; Zhu, Wenbo; Cai, Jing; Yan, Guangmei; Liang, Jiankai; Lin, Yuan

Guo, Li; Hu, Cheng; Liu, Yang; Chen, Xiaoyu; Song, Deli; Shen, Runling; Liu, Zhanzhen; Jia, Xudong; Zhang, Qinfen; Gao, Yuanzhu; Deng, Zhezhi; Zuo, Tao; Hu, Jun; Zhu, Wenbo; Cai, Jing; Yan, Guangmei; Liang, Jiankai; Lin, Yuan.

Afiliación

Guo L; Department of Pharmacology, Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Hu C; Department of Urology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.
Liu Y; Department of Pharmacology, Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Chen X; Department of Pharmacology, Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Song D; Department of Pharmacology, Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Shen R; Department of Pharmacology, Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Liu Z; Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China and Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China.
Jia X; School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.
Zhang Q; School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.
Gao Y; School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.
Deng Z; Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, 510080, China.
Zuo T; Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China and Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China.
Hu J; Department of Pharmacology, Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Zhu W; Department of Pharmacology, Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Cai J; Department of Pharmacology, Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Yan G; Department of Pharmacology, Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Liang J; Department of Pharmacology, Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China. liangjk5@mail.sysu.edu.cn.
Lin Y; Department of Pharmacology, Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China. liny96@mail.sysu.edu.cn.

Nat Commun ; 14(1): 3410, 2023 06 09.

Article en En | MEDLINE | ID: mdl-37296165

Asunto(s)

Neoplasias; Viroterapia Oncolítica; Virus Oncolíticos; Animales; Virus Oncolíticos/genética; Neoplasias/terapia

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Virus Oncolíticos / Viroterapia Oncolítica / Neoplasias Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: China

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