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Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial.
Rouphael, Nadine G; Branche, Angela R; Diemert, David J; Falsey, Ann R; Losada, Cecilia; Baden, Lindsey R; Frey, Sharon E; Whitaker, Jennifer A; Little, Susan J; Kamidani, Satoshi; Walter, Emmanuel B; Novak, Richard M; Rupp, Richard; Jackson, Lisa A; Babu, Tara M; Kottkamp, Angelica C; Luetkemeyer, Anne F; Immergluck, Lilly C; Presti, Rachel M; Bäcker, Martín; Winokur, Patricia L; Mahgoub, Siham M; Goepfert, Paul A; Fusco, Dahlene N; Atmar, Robert L; Posavad, Christine M; Netzl, Antonia; Smith, Derek J; Telu, Kalyani; Mu, Jinjian; McQuarrie, Lisa J; Makowski, Mat; Makhene, Mamodikoe K; Crandon, Sonja; Montefiori, David C; Roberts, Paul C; Beigel, John H.
Afiliación
  • Rouphael NG; Hope Clinic, Emory University, Decatur, Georgia.
  • Branche AR; Vaccine and Treatment Evaluation Unit, University of Rochester, New York.
  • Diemert DJ; George Washington Vaccine Research Unit, George Washington University, Washington, District of Columbia.
  • Falsey AR; Vaccine and Treatment Evaluation Unit, University of Rochester, New York.
  • Losada C; Hope Clinic, Emory University, Decatur, Georgia.
  • Baden LR; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  • Frey SE; Center for Vaccine Development, Saint Louis University, Missouri.
  • Whitaker JA; Department of Molecular Virology and Microbiology and Department of Medicine, Baylor College of Medicine, Houston, Texas.
  • Little SJ; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla.
  • Kamidani S; Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta.
  • Walter EB; Department of Pediatrics, Emory University, Atlanta, Georgia.
  • Novak RM; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina.
  • Rupp R; Project WISH, University of Illinois at Chicago, Chicago, Illinois.
  • Jackson LA; Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas.
  • Babu TM; Kaiser Permanente Washington Health Research Institute, Seattle, Washington.
  • Kottkamp AC; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington.
  • Luetkemeyer AF; Vaccine and Treatment Evaluation Unit, Manhattan Research Clinic, New York University Grossman School of Medicine, New York, New York.
  • Immergluck LC; Department of Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, California.
  • Presti RM; Clinical Research Center, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia.
  • Bäcker M; Department of Medicine, Washington University School of Medicine, St Louis, Missouri.
  • Winokur PL; Vaccine and Treatment Evaluation Unit, Long Island Research Clinic, New York University Long Island School of Medicine, Mineola, New York.
  • Mahgoub SM; Department of Medicine, University of Iowa College of Medicine, Iowa City, Iowa.
  • Goepfert PA; Howard University College of Medicine, Howard University Hospital, Washington, District of Columbia.
  • Fusco DN; Department of Medicine, University of Alabama at Birmingham, Alabama.
  • Atmar RL; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.
  • Posavad CM; Department of Molecular Virology and Microbiology and Department of Medicine, Baylor College of Medicine, Houston, Texas.
  • Netzl A; Infectious Diseases Clinical Research Consortium (IDCRC) Laboratory Operations Unit, Fred Hutchinson Cancer Center, Seattle, Washington.
  • Smith DJ; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington.
  • Telu K; Centre for Pathogen Evolution, Department of Zoology, University of Cambridge, United Kingdom.
  • Mu J; Centre for Pathogen Evolution, Department of Zoology, University of Cambridge, United Kingdom.
  • McQuarrie LJ; The Emmes Company, LLC, Rockville, Maryland.
  • Makowski M; The Emmes Company, LLC, Rockville, Maryland.
  • Makhene MK; The Emmes Company, LLC, Rockville, Maryland.
  • Crandon S; The Emmes Company, LLC, Rockville, Maryland.
  • Montefiori DC; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
  • Roberts PC; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
  • Beigel JH; Department of Surgery, Duke University, Durham, North Carolina.
J Infect Dis ; 228(12): 1662-1666, 2023 12 20.
Article en En | MEDLINE | ID: mdl-37561027
ABSTRACT
We compared the serologic responses of 1 dose versus 2 doses of a variant vaccine (Moderna mRNA-1273 Beta/Omicron BA.1 bivalent vaccine) in adults. A 2-dose boosting regimen with a variant vaccine did not increase the magnitude or the durability of the serological responses compared to a single variant vaccine boost.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vacuna nCoV-2019 mRNA-1273 Tipo de estudio: Clinical_trials Límite: Adult / Humans Idioma: En Revista: J Infect Dis Año: 2023 Tipo del documento: Article País de afiliación: Georgia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vacuna nCoV-2019 mRNA-1273 Tipo de estudio: Clinical_trials Límite: Adult / Humans Idioma: En Revista: J Infect Dis Año: 2023 Tipo del documento: Article País de afiliación: Georgia