Cinchona-Alkaloid-Derived NNP Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of ß-Keto Ester.
J Org Chem
; 89(3): 1446-1457, 2024 Feb 02.
Article
en En
| MEDLINE
| ID: mdl-38267199
ABSTRACT
The Ir-catalyzed asymmetric hydrogenation of ß-keto esters with Cinchona-alkaloid-derived NNP ligands has been developed. ß-Hydroxy esters of opposite configuration were afforded smoothly with 91.5-99.1 and 81.6-99.3% ee, respectively, using NNP L2 and L7 derived from quinidine and quinine separately even on the gram scale. The protocol for the preparation of ß-hydroxy esters of opposite configuration by the simple conversion of ligand configurations offered further opportunities for the synthesis of biologically active molecules and drugs.
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01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Año:
2024
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Article