Updates on WHO classification for small round cell tumors: Ewing sarcoma vs. everything else.
Hum Pathol
; 147: 101-113, 2024 May.
Article
en En
| MEDLINE
| ID: mdl-38280658
ABSTRACT
The WHO Classification of Soft Tissue and Bone Tumours currently recognizes four categories of undifferentiated small round cell sarcoma Ewing sarcoma, round cell sarcoma with EWSR1-non-ETS fusions including NFATc2 and PATZ1, CIC-rearranged sarcoma, and sarcoma with BCOR genetic alterations. These neoplasms frequently pose significant diagnostic challenges due to rarity and overlapping morphologic and immunohistochemical findings. Further, molecular testing, with accompanying pitfalls, may be needed to establish a definitive diagnosis. This review summarizes the clinical, histologic, immunohistochemical, and molecular features of these neoplasms. In addition, differential diagnosis and areas of uncertainty and ongoing investigation are discussed.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sarcoma de Ewing
/
Organización Mundial de la Salud
/
Neoplasias Óseas
/
Biomarcadores de Tumor
/
Sarcoma de Células Pequeñas
Límite:
Humans
Idioma:
En
Revista:
Hum Pathol
Asunto de la revista:
PATOLOGIA
Año:
2024
Tipo del documento:
Article