Real-world data on polysomnography- and patient-reported outcomes in hypoglossal nerve stimulation and auto-titrating positive airway pressure therapy for obstructive sleep apnea.
Respir Med
; 232: 107750, 2024 Oct.
Article
en En
| MEDLINE
| ID: mdl-39084269
ABSTRACT
BACKGROUND:
Few data are available comparing first-line positive airway pressure (PAP) therapy of obstructive sleep apnea (OSA), especially auto-adjusting PAP (aPAP), with second-line hypoglossal nerve stimulation (HGNS) therapy. The aim of this study was to directly compare these therapeutic options by standard polysomnography (PSG)-related parameters and patient-reported outcomes in comparable groups.METHODS:
20 patients (aged 57.30 ± 8.56 years; 6 female) were included in the HGNS and 35 patients (aged 56.83 ± 9.20 years; 9 female) were included in the aPAP group. In both groups participants had to fit the current guideline criteria for HGNS treatment. Groups were compared by analysis of covariance (ANCOVA) using inverse propensity score weighting.RESULTS:
Propensity scores did not differ between groups. Pre-therapeutic AHI (HGNS 40.22 ± 12.78/h; aPAP 39.23 ± 12.33/h) and ODI (HGNS 37.9 ± 14.7/h, aPAP 34.58 ± 14.74/h) were comparable between the groups. After 413.6 ± 116.66 days (HGNS) and 162.09 ± 140.58 days (aPAP) of treatment AHI (HGNS 30.22 ± 17.65/h, aPAP group 4.71 ± 3.42/h; p < 0.001) was significantly higher in the HGNS group compared to the aPAP group. However, epworth sleepiness scale (ESS) was post-interventionally significantly lower in the HGNS group compared to the aPAP group (pretherapeutic HGNS 13.32 ± 5.81 points, aPAP 9.09 ± 4.71 points; posttherapeutic HGNS 7.17 ± 5.06 points; aPAP 8.38 ± 5.41 points; p < 0.01).CONCLUSION:
These are novel real-world data. More research on the key parameters regarding titration of the HGNS neurostimulation parameter tuning and on the impact of factors influencing HGNS adherence is needed.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Terapia por Estimulación Eléctrica
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Polisomnografía
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Apnea Obstructiva del Sueño
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Presión de las Vías Aéreas Positiva Contínua
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Medición de Resultados Informados por el Paciente
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Nervio Hipogloso
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Respir Med
Año:
2024
Tipo del documento:
Article