Platelet-derived growth factor (PDGF)-AB-mediated phosphorylation of PDGF beta receptors.
Biochem J
; 297 ( Pt 2): 379-84, 1994 Jan 15.
Article
en En
| MEDLINE
| ID: mdl-8297345
ABSTRACT
Platelet-derived growth factor (PDGF) stimulates the proliferation of Balb/c-3T3 fibroblasts through binding and subsequent activation of PDGF receptors. Activation of the PDGF receptors has been proposed to involve receptor dimerization. PDGF-AB has been shown to bind PDGF alpha and beta receptor subunits to form PDGF alpha beta and alpha alpha receptor dimers. In this paper we demonstrate that, following the down-regulation of PDGF alpha receptors, the binding of PDGF-AB to beta receptors occurred at 37 degrees C but not at 4 degrees C. PDGF-AB stimulated the phosphorylation of PDGF beta receptor monomers in cells depleted of PDGF alpha receptors by prior exposure to PDGF-AA.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factor de Crecimiento Derivado de Plaquetas
/
Receptores del Factor de Crecimiento Derivado de Plaquetas
/
Proteínas Tirosina Quinasas Receptoras
Límite:
Animals
Idioma:
En
Revista:
Biochem J
Año:
1994
Tipo del documento:
Article