Zika virus RNA excretion in sweat with concomitant detection in other body fluid specimens
Menezes-Neto, Armando; Castilho, Marcia da Costa; Calvet, Guilherme Amaral; Kara, Edna Oliveira; Bôtto-Menezes, Camila Helena Aguiar; Lacerda, Marcus Vinícius Guimarães; Departamento de Doenças de Condições Crônicas e Infecções Sexualmente TransmissíveisPereira, Gerson Fernando Mendes; Departamento de Doenças de Condições Crônicas e Infecções Sexualmente TransmissíveisGiozza, Silvana Pereira; Departamento de Saúde PúblicaBermudez, Ximena Pamela Diaz; Lima, Noemia Santana; Modjarrad, Kayvon; Broutet, Nathalie; de Filippis, Ana Maria Bispo; Franca, Rafael Freitas Oliveira.
Mem. Inst. Oswaldo Cruz
; 115: e200339, 2020. tab, graf
Artigo
em Inglês
| LILACS | ID: biblio-1154865
We evaluated sweat, blood and urine specimens obtained from an ongoing cohort study in Brazil. Samples were collected at pre-established intervals after the initial rash presentation and tested for Zika virus (ZIKV) RNA presence by real-time reverse transcriptase polymerase chain reaction (rRT-PCR). From 254 participants with confirmed infection, ZIKV RNA was detected in the sweat of 46 individuals (18.1%). Sweat presented a median cycle threshold (Ct) of 34.74 [interquartile range (IQR) 33.44-36.04], comparable to plasma (Ct 35.96 - IQR 33.29-36.69) and higher than urine (Ct 30.78 - IQR 28.72-33.22). Concomitant detection with other specimens was observed in 33 (72%) of 46 participants who had a positive result in sweat. These findings represent an unusual and not yet investigated virus shedding through eccrine glands.
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