Human papillomavirus vaccine efficacy in the prevention of anogenital warts: systematic review and meta-analysis / Eficacia de la vacuna contra el virus del papiloma humano en la prevención de verrugas anogenitales: revisión sistemática y metanálisis
Tejada, Romina A; Vargas, Kris G; Benites-Zapata, Vicente; Mezones-Holguín, Edward; Bolaños-Díaz, Rafael; Hernandez, Adrián V.
Salud pública Méx
; 59(1): 84-94, Jan.-Feb. 2017. tab, graf
Artigo
em Inglês
| LILACS | ID: biblio-846045
Abstract
Objective:
To review evidence on the efficacy of HPV vaccines in the prevention of non-cancer lesions (anogenital warts [AGW], recurrent laryngeal papillomatosis and oral papillomatosis). Materials andmethods:
We conducted a systematic review of randomized trials. We performed random effect models and effects were reported as relative risks (RR) and their confidence intervals (95%CI) following both intention to treat (ITT) and per protocol (PP) analyses.Results:
We included six studies (n=27 078). One study was rated as high risk of bias. One study could not be included in the meta-analysis because it provided combined results. We found that quadrivalent vaccine reduced the risk of AGW by 62% (RR 0.38, 95%CI0.32-0.45, I20%) in the ITT analysis and by 95% (RR 0.05, 95%CI0.01-0.25, I266%) in the PP analysis. Subgroup analyses of studies in women or with low-risk of bias provided similar results.Conclusion:
HPV quadrivalent vaccine is efficacious in preventing AGW in men and women.
Biblioteca responsável:
BR1.1
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